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Department Chemie
Technische und Makromolekulare Chemie
Prof. Dr.-Ing. Guido Grundmeier
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Nanobiomaterials

The Nanobiomaterials group investigates the structure and behavior of biomolecular systems with the aim to develop novel and improved biomedical materials, assays, and therapies. Our research is focused on the following topics.

DNA nanotechnology

On the Stability of DNA Origami Nanostructures in Low‐Magnesium Buffers (Kielar et al., Angewandte Chemie International Edition 2018)

The DNA origami technique enables the fast, high-yield synthesis of arbitrarily shaped 2D and 3D nanostructures by exploiting the strong specificity of Watson−Crick base pairing. It employs a long, single-stranded DNA scaffold which is folded into the desired shape by a suitable (i.e., complementary) set of designed short synthetic oligonucleotides, called staple strands. The sequence of each staple strand is designed to facilitate multiple binding events with different segments of the scaffold strand, thus forcing the scaffold to fold into an arbitrary, yet well defined shape. The resulting DNA origami nanostructures may serve as spatially addressable molecular breadboards that enable the controlled arrangement of biomolecules and nanoparticles with nanometer precision. Our current research is focused on further advancing the DNA origami technique toward novel applications in drug discovery, drug delivery, and single-molecule biophysics.

Amyloid aggregation

Adsorption and Fibrillization of Islet Amyloid Polypeptide at Self-Assembled Monolayers Studied by QCM-D, AFM, and PM-IRRAS (Hajiraissi et al., Langmuir 2018)

The denaturation and aggregation of proteins into amyloid aggregates play important roles in the development of various degenerative diseases including Alzheimer's disease, Parkinson's disease, and type 2 diabetes mellitus. In the course of these diseases, partially unfolded proteins associate with one another and form nanoscale fibrillar structures with different morphologies. Amyloid aggregation kinetics and aggregate structure are affected by many different factors, including pH, ionic strength, protein concentration, and the interaction with interfaces. We are, therefore, investigating the molecular mechanisms responsible for the aggregation of different medically relevant proteins and peptides. We are particularly interested in the role of surface effects that may promote or inhibit amyloid fibril formation.

Nanostructured biointerfaces

Low-aspect ratio nanopatterns on bioinert alumina influence the response and morphology of osteoblast-like cells (Wittenbrink et al., Biomaterials 2015)

The interaction of adhering cells with biological and artificial surfaces is to a great extent controlled by the adsorption and conformation of different proteins from the surrounding medium. Understanding and ultimately controlling the behavior of biomolecules at surfaces thus represents an important prerequisite for various applications in tissue engineering, regenerative medicine, and cell therapy. We, therefore, study the interaction of biomolecules with solid surfaces in order to shed light on the fundamental processes that govern cellular response. We are particularly interested in the influence of topographic surface features with nanoscale dimensions which, despite their small size, can have tremendous effects on cellular response including  morphology, proliferation, and differentiation. 

Group leader

PD Dr. Adrian Keller

Technische Chemie - Arbeitskreis Grundmeier

Group leader "Nanobiomaterials"

Adrian Keller
Telefon:
+49 5251 60-5722
Fax:
+49 5251 60-3244
Büro:
NW2.831
Web:

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