Synthesis with renewable raw materials and biologically active compounds
We strive to apply methods developed within our group to the synthesis of interesting target structures. An important aspect in this context is, inter alia, the use of renewable resources instead of fossil-based materials, which can significantly mitigate the carbon footprint of chemical products. In this regard, we are working with CO₂, plant-based oils and fats, sugars as well as other renewables as starting materials for biologically active and other high-value products.
Ambrocenide® is a terpene based powerful fragrance. We recently reported an alternative synthesis starting from a readily available terpene derivative.
Publications
Calcium-Based Catalytic System for the Synthesis of Bio-Derived Cyclic Carbonates under Mild Conditions
L. Longwitz, J. Steinbauer, A. Spannenberg, T. Werner, ACS Catalysis 8 (2017) 665–672.
Calcium-Based Catalytic System for the Synthesis of Bio-Derived Cyclic Carbonates under Mild Conditions
L. Longwitz, J. Steinbauer, A. Spannenberg, T. Werner, ACS Catalysis 8 (2018) 665–672.
Life Cycle Assessment for the Organocatalytic Synthesis of Glycerol Carbonate Methacrylate
H. Büttner, C. Kohrt, C. Wulf, B. Schäffner, K. Groenke, Y. Hu, D. Kruse, T. Werner, ChemSusChem 12 (2019) 2701–2707.
Catalytic Approaches to Monomers for Polymers Based on Renewables
B.M. Stadler, C. Wulf, T. Werner, S. Tin, J.G. de Vries, ACS Catalysis 9 (2019) 8012–8067.
Intramolecular Base-Free Catalytic Wittig Reaction: Synthesis of Benzoxepinones
A. Grandane, L. Longwitz, C. Roolf, A. Spannenberg, H. Murua Escobar, C. Junghanss, E. Suna, T. Werner, The Journal of Organic Chemistry 84 (2019) 1320–1329.
Reduction of Activated Alkenes by PIII/PV Redox Cycling Catalysis
L. Longwitz, T. Werner, Angewandte Chemie 132 (2020) 2782–2785.
Novel processes for preparing cis-cedrandiol
T. Werner, V. Stefanow, A. Grandane, J. Panten, M. Eh, International Patent Number: WO2022/002380 A1, Patent Classification: -, 2020.
Reduction of Activated Alkenes by PIII/PV Redox Cycling Catalysis
L. Longwitz, T. Werner, Angewandte Chemie International Edition 59 (2020) 2760–2763.
Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors
A. Grandane, A. Nocentini, T. Werner, R. Zalubovskis, C.T. Supuran, Bioorganic and Medicinal Chemistry 28 (2020).
Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones
T. Werner, A. Grandane, L. Pudnika, I. Domraceva, R. Zalubovskis, Synthesis 53 (2021) 3545–3554.
Stereoselective Synthesis of acis-Cedrane-8,9-diol as a Key Intermediate for an Amber Odorant
V. Stefanow, A. Grandane, M. Eh, J. Panten, A. Spannenberg, T. Werner, Organic Process Research & Development 25 (2021) 89–97.
Stereoselective Synthesis of acis-Cedrane-8,9-diol as a Key Intermediate for an Amber Odorant
V. Stefanow, A. Grandane, M. Eh, J. Panten, A. Spannenberg, T. Werner, Organic Process Research & Development 25 (2021) 89–97.
AMPA-15N – Synthesis and application as standard compound in traceable degradation studies of glyphosate
M.A. Wirth, L. Longwitz, M. Kanwischer, P. Gros, P. Leinweber, T. Werner, Ecotoxicology and Environmental Safety 225 (2021).
Lupane derivatives: Design, isolation, synthesis and evaluation of antiplasmodial activity against Plasmodium falciparum 3D7 strain
P. Yemback, K.O. Eyong, N.M. Efange, M.HK. Kamdem, D.T. Ndinteh, P.O. Odumosu, G.N. Folefoc, L. Ayong, T. Werner, Phytochemistry Letters 57 (2023) 26–35.
Chemoenzymatic Synthesis of Chiral Building Blocks Based on the Kinetic Resolution of Glycerol‐Derived Cyclic Carbonates
C. Terazzi, A. Spannenberg, J. von Langermann, T. Werner, ChemCatChem 15 (2023).
Design, isolation, synthesis, and mechanistic insight of flavonoids isolated from Beilschmiedia obscura, as potential α-glucosidase inhibitors
S.L. Nyemeck, K.O. Eyong, R. Bidingha, M.HK. Kamdem, D.T. Ndinteh, P.O. Odumosu, G.N. Folefoc, D.C. Bilanda, A.E. Egbe, T. Werner, B.D. Bekono, F. Ntie-Kang, Phytochemistry Letters 62 (2024) 59–67.
Straightforward Access to Terpene-Based 1,2-Diols and Their Acetals as Fragrance Ingredients
V. Stefanow, L. Kell, A. Leduskrasta, M. Eh, J. Panten, T. Werner, The Journal of Organic Chemistry 90 (2025) 12877–12887.
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